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Volume 39, Number 6, December 2006

Infectious pathogens in pediatric patients with primary immunodeficiencies


Shu-Hua Chang, Yao-Hsu Yang, Bor-Luen Chiang
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan

Received: June 30, 2005    Revised: March 24, 2006    Accepted: March 30, 2006   

 

Corresponding author:

Dr. Bor-Luen Chiang, MD, PhD, Department of Pediatrics, National Taiwan University Hospital, No.7, Chung Shan South Road, Taipei 100, Taiwan. E-mail: gicmbor@ha.mc.ntu.edu.tw This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

 



 

Background and purpose: 

Primary immunodeficiency diseases (PIDs) are rare disorders. Unusual infections often guide the initial investigation for immunodeficiency.

 



 

Methods:

In order to ascertain the organisms that lead to a predisposition for PIDs, we reviewed the charts of 92 children diagnosed with PIDs at the National Taiwan University Hospital between March 1984 and March 2004.

 



 

Results:

Pneumonia was diagnosed in 92%, 81%, and 76.5% of patients with antibody, combined, and cellular deficiencies, respectively. Other major illnesses were similar in the 3 groups and included bronchiolitis, acute gastroenteritis, otitis media, and bacteremia. Skin abscess, pneumonia, and lymphadenitis (54.5%, 45%, and 27% of cases, respectively) were the most common infections in patients with phagocyte defects. Organisms were speciated in only 44.8% of infection episodes. Most viral infections were diagnosed by traditional and time-consuming viral culture. Prophylactic antibiotics were prescribed to 9 out of the 92 patients with PIDs.

 



 

Conclusion:

Early recognition of PIDs requires that practitioners be aware of the infection characteristics, and subsequent reliable and rapid molecular diagnosis are needed in such immunocompromised patients.

 



 

Key words:

Etiology, infection, immunologic deficiency syndromes, phagocytes

 



 

J Microbiol Immunol Infect 2006;39:503-515