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Volume 39, Number 6, December 2006

Nasal carriage of Staphylococcus aureus among healthy adults


Chong Seng Choi, Chow Suet Yin, Afra Abu Bakar, Zamberi Sakewi, Nyi Nyi Naing, Farida Jamal, Norlijah Othman
Department of Clinical Laboratory Sciences, Universiti Putra Malaysia, Selangor; Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan; and Department of Human Growth and Development, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

Received: January 7, 2006    Revised: March 15, 2006    Accepted: March 24, 2006   

 

Corresponding author:

Dr. Norlijah Othman, Department of Human Growth and Development, Faculty of Medicine and Health Sciences, University Putra Malaysia, Jalan Masjid 50586, Kuala Lumpur, Malaysia. E-mail: nor@medic.upm.edu.my This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

 



 

Background and purpose: 

Data on the carriage rate and antibiotic sensitivity pattern of Staphylococcus aureus strains prevalent in the community are not available for many developing countries including Malaysia. To estimate the extent of community S. aureus transmission, in particular methicillin-resistant S. aureus (MRSA), the prevalence of S. aureus nasal colonization in a population of healthy adults was determined. Factors associated with S. aureus nasal carriage and antibiotic sensitivity patterns of the isolates were also analyzed.

 



 

Methods:

A cross-sectional study involving 346 adults was conducted. Nasal swabs were examined for the presence of S. aureus. Epidemiological information concerning risk factors for nasal carriage was also obtained. Antibiotic susceptibility testing was performed using the disk diffusion method according to the National Committee for Clinical Laboratory Standards guidelines. MRSA strains isolated were further subjected to pulse-field gel electrophoresis analysis.

 



 

Results:

The prevalence of S. aureus nasal carriage was 23.4%. The findings also revealed that ex-smokers (95% confidence interval [CI] 1.08-6.32, p=0.033) and oral contraceptive users (95% CI 1.12-21.67, p=0.035) were more likely to harbor S. aureus. One person was colonized with MRSA, which was different from the hospital strain.

 



 

Conclusion:

MRSA nasal colonization was found to be low outside of the health care environment. Smokers and oral contraceptive users have high nasal carrier rates.

 



 

Key words:

Carrier state, methicillin, nasal mucosa, prevalence, resistance, Staphylococcus aureus


 



 

J Microbiol Immunol Infect 2006;39:458-464.