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Volume 40, Number 1, February 2007

Successful treatment of life-threatening melioidosis with activated protein C and meropenem

Che-Kim Tan, Khee-Siang Chan, Wen-Liang Yu, Chin-Ming Chen, Kuo-Chen Cheng
Department of Intensive Care Medicine, Chi-Mei Medical Center, Tainan, Taiwan

Received: May 2, 2006    Revised: June 8, 2006    Accepted: July 13, 2006   


Corresponding author:

Wen-Liang Yu, MD, Department of Intensive Care Medicine, Chi-Mei Medical Center, 901, Chunghua Rd., Yungkang City, 710 Tainan County, Taiwan. E-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it




Melioidosis is an endemic disease in southeast Asia and northern Australia, caused by Burkholderia pseudomallei. A typhoon-related outbreak occurred in southern Taiwan in July 2005. High mortality in melioidosis associated with bacteremic pneumonia and septic shock. We report a patient with life-threatening melioidosis who developed rapid progression of bacteremic pneumonia with acute respiratory distress syndrome, septic shock and multiple organ dysfunction and was successfully treated with recombinant human activated protein C (rhAPC) and meropenem. Although rhAPC has been reported to reduce the mortality of severe septic shock caused by various pathogens, to our best knowledge, this is the first reported case of rhAPC application in life-threatening melioidosis


Key words:

Burkholderia pseudomallei; Melioidosis; Pneumonia; Recombinant proteins; Respiratory distress syndrome, adult; Shock, septic; Thienamycins



J Microbiol Immunol Infect 2007;40:83-87.