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Volume 40, Number 2, April 2007

Epstein-Barr virus-associated smooth muscle tumor in patients with acquired immunodeficiency syndrome

Ka-Hing Wong, Kenny Chi-Wai Chan, Shui-Shan Lee, Sik-To Lai, Nelson Lee, Clive Cockram, Wai-Sang Poon, Tak-Yin Tsang, Yuk-Keung Tso, Ka-Fai To
Integrated Treatment Centre, Special Preventive Programme, Centre for Health Protection, Department of Health, Hong Kong; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong; Department of Medicine, Princess Margaret Hospital, Hong Kong; Departments of Medicine and Therapeutics, and Surgery, The Chinese University of Hong Kong, Hong Kong; and Department of Anatomical Pathology, Prince of Wales Hospital, Hong Kong

Received: January 18, 2006    Revised: March 20, 2006    Accepted: April 2, 2006   


Corresponding author:

Dr. K.H. Wong, Special Preventive Programme, Public Health Services Branch, Centre for Health Protection, Department of Health, 5/F, Yaumatei Jockey Club Clinic, 145 Battery Street, Kowloon, Hong Kong. E-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it




The study was presented in part at the XVIth International AIDS Conference, Toronto, Canada, August 13-18, 2006.
Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is a recognized but uncommon disease that is found to occur in patients with immunocompromised conditions such as acquired immunodeficiency syndrome (AIDS). These tumors may be multifocal and located at unusual sites, such as the brain and liver. This report describes the case of 2 AIDS patients with EBV-associated SMT and highlights the features and outcome of this rare but potentially important tumor in human immunodeficiency virus management.



Key words:

Acquired immunodeficiency syndrome; Epstein-Barr virus infections; In situ hybridization; Smooth muscle tumor


J Microbiol Immunol Infect. 2007;40:173-177.