Epstein-Barr virus-associated smooth muscle tumor in patients with acquired immunodeficiency syndrome
Ka-Hing Wong, Kenny Chi-Wai Chan, Shui-Shan Lee, Sik-To Lai, Nelson Lee, Clive Cockram, Wai-Sang Poon, Tak-Yin Tsang, Yuk-Keung Tso, Ka-Fai To
Integrated Treatment Centre, Special Preventive Programme, Centre for Health Protection, Department of Health, Hong Kong; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong; Department of Medicine, Princess Margaret Hospital, Hong Kong; Departments of Medicine and Therapeutics, and Surgery, The Chinese University of Hong Kong, Hong Kong; and Department of Anatomical Pathology, Prince of Wales Hospital, Hong Kong
Received: January 18, 2006 Revised: March 20, 2006 Accepted: April 2, 2006
The study was presented in part at the XVIth International AIDS Conference, Toronto, Canada, August 13-18, 2006.
Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is a recognized but uncommon disease that is found to occur in patients with immunocompromised conditions such as acquired immunodeficiency syndrome (AIDS). These tumors may be multifocal and located at unusual sites, such as the brain and liver. This report describes the case of 2 AIDS patients with EBV-associated SMT and highlights the features and outcome of this rare but potentially important tumor in human immunodeficiency virus management.
Acquired immunodeficiency syndrome; Epstein-Barr virus infections; In situ hybridization; Smooth muscle tumor
J Microbiol Immunol Infect. 2007;40:173-177.