Plasma soluble CD30 level correlates negatively with age in children
Jung-Yu Chen, Lin-Shien Fu, Jao-Jia Chu, Hou-Chuan Chen, Chin-Shiang Chi
Division of Immunology, Rheumatology and Allergy, Department of Pediatrics, and Divisions of Chest Medicine and 3Pediatric Surgery, Taichung Veterans General Hospital, Taichung, Taiwan
Received: January 6, 2006 Revised: June 1, 2006 Accepted: June 12, 2006
Background and purpose:
Atopic diseases are thought to be associated with cytokine-mediated immune dysregulation, for example, a T helper cell type 1/2 (Th1/Th2) imbalance. CD30 is proposed to be one of the surrogate markers for Th2 immunity. In this study, we investigated whether CD30 is a good marker for atopy and Th2 predominance in a pediatric population.
This study included 61 children with atopy and 27 normal controls. The expression of CD30 on the surface of T and B lymphocytes and soluble CD30 (sCD30) in plasma was determined.
There was no difference in the surface expression of CD30 on B or T lymphocytes. Similarly, sCD30 levels in plasma were not different between the 2 groups. Nevertheless, we found a strong negative correlation between sCD30 and age in the control group (r = –0.72, p<0.001; sCD30 = 76.1 – 5.18 × age) as well as in the atopy group (r = –0.45, p<0.01; sCD30 = 61.1 – 3.56 × age).
An inverse relationship was found between age and sCD30 level in children. However, our findings suggest that CD30 is not a good marker for atopic disease and that further studies on sCD30 levels must take age into consideration.
Age factors; Antigens, CD30; Cytokines; T-lymphocytes
J Microbiol Immunol Infect. 2007;40:168-172.