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Volume 40, Number 4, August 2007

Adenosine deaminase activity in serum of patients with hepatitis — a useful tool in monitoring clinical status

Selçuk Kaya, Emel Sesli Çetin, Buket Cicioglu Aridogan, Salih Arikan, Mustafa Demirci
Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey

Received: November 14, 2006    Revised: January 20, 2007    Accepted: February 15, 2007   


Corresponding author:

Dr. Selçuk Kaya, Istanbul Cad. No: 52 Kat: 4/14, Isparta 32100, Turkey. E-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it



Background and purpose: 

The evaluation of adenosine deaminase (ADA) activity in sera of patients with hepatitis should be considered a useful tool in the monitoring of their clinical status. In this study, we aimed to determine the relationship between viral load, transaminase levels, and serum ADA levels in hepatitis B virus (HBV)- and hepatitis C virus (HCV)-infected patients.




Seventy three patients with hepatitis B, 71 patients with hepatitis C and 40 healthy individuals were included. Patients with HBV and HCV infections were classified into 3 groups according to viral load. Serum ADA levels were investigated by colorimetric assay.




Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and ADA levels of HBV- and HCV-infected patients were higher than those of the control group. These differences were statistically significant for the levels of all enzymes in HCV-infected patients (p<0.05), and all except AST (p>0.05) in HBV-infected patients. ADA levels of HBV-infected patients with high viral loads were higher than those in HBV-infected patients with intermediate and low viral loads, and the difference was detectably significant between patients with high and intermediate viral loads. Evaluation of HCV-infected patients according to viral load showed no statistically significant relationship between viral load and serum ADA, ALT, and AST levels (p>0.05). HBV- and HCV-infected patients with high ALT and AST levels showed statistically significantly higher levels of ADA than patients with normal ALT and AST levels (p<0.001).




We suggest that serum ADA levels are associated more with the level of serum transaminases than viral load in HBV- and HCV-infected patients. In the treatment of patients with hepatitis, serum ADA levels should be considered a useful tool for the monitoring of liver condition.



Key words:

Adenosine deaminase; Hepacivirus; Hepatitis B virus; Viral load



J Microbiol Immunol Infect. 2007;40:288-292.