Multidrug-resistant Acinetobacter baumannii in ventilator-associated pneumonia at a medical center in southern Taiwan
Ming-Hsin Mai, Hung-Chin Tsai, Susan Shin-Jung Lee, Yung-Hsing Wang, Yao-Shen Chen, Shue-Ren Wann, Yung-Ching Liu
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung; and 2College of Medicine, National Yang-Ming University, Taipei, Taiwan
Received: April 20, 2006 Revised: July 30, 2006 Accepted: August 11, 2006
Background and purpose:
To evaluate the significance of multidrug-resistant Acinetobacter baumannii (MDRAB)- related ventilator-associated pneumonia at a medical center in southern Taiwan.
We retrospectively reviewed the medical records of patients with MDRAB isolated from sputum and described the characteristics of these patients. Patients were divided into 2 groups according to their clinical pulmonary infection scores (CPIS), and their host factors and outcomes compared.
In the patient group with significant MDRAB-related lung infection, Acute Physiology and Chronic Health Evaluation II scores were significantly higher than in those patients with lower CPIS scores (<6). However, the clinical outcomes, including the duration of hospitalization after isolation of MDRAB and mortality rate, were not different.
Our investigation showed that significant lung infections with MDRAB isolation did not result in prolonged hospitalization or increased mortality. The initial clinical severity of the group with significant MDRAB-related lung infection was significantly greater than in the other. We propose that MDRAB-related pneumonia should be regarded as a signal of the clinical severity of the patient rather than as a prognostic factor.
Acinetobacter baumannii; Drug resistance, multiple, bacterial; Pneumonia, ventilator-associated; Sulbactam
J Microbiol Immunol Infect. 2007;40:401-405.