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Volume 40, Number 5, October 2007

Multidrug-resistant Acinetobacter baumannii in ventilator-associated pneumonia at a medical center in southern Taiwan


Ming-Hsin Mai, Hung-Chin Tsai, Susan Shin-Jung Lee, Yung-Hsing Wang, Yao-Shen Chen, Shue-Ren Wann, Yung-Ching Liu
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung; and 2College of Medicine, National Yang-Ming University, Taipei, Taiwan

Received: April 20, 2006    Revised: July 30, 2006    Accepted: August 11, 2006   

 

Corresponding author:

Dr. Yung-Ching Liu, Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung, Taiwan. E-mail: Dr. Yung-Ching Liu This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

 



 

Background and purpose: 

To evaluate the significance of multidrug-resistant Acinetobacter baumannii (MDRAB)- related ventilator-associated pneumonia at a medical center in southern Taiwan.

 



 

Methods:

We retrospectively reviewed the medical records of patients with MDRAB isolated from sputum and described the characteristics of these patients. Patients were divided into 2 groups according to their clinical pulmonary infection scores (CPIS), and their host factors and outcomes compared.

 



 

Results:

In the patient group with significant MDRAB-related lung infection, Acute Physiology and Chronic Health Evaluation II scores were significantly higher than in those patients with lower CPIS scores (<6). However, the clinical outcomes, including the duration of hospitalization after isolation of MDRAB and mortality rate, were not different.

 



 

Conclusion:

Our investigation showed that significant lung infections with MDRAB isolation did not result in prolonged hospitalization or increased mortality. The initial clinical severity of the group with significant MDRAB-related lung infection was significantly greater than in the other. We propose that MDRAB-related pneumonia should be regarded as a signal of the clinical severity of the patient rather than as a prognostic factor.

 



 

Key words:

Acinetobacter baumannii; Drug resistance, multiple, bacterial; Pneumonia, ventilator-associated; Sulbactam


 



 

J Microbiol Immunol Infect. 2007;40:401-405.