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Volume 33, Number 3, September 2000

Molecular biology of human immunodeficiency virus type 1

Wei-Kung Wang, Mao-Yuan Chen, Che-Yen Chuang, Kuan-Teh Jeang, Li-Min Huang
Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, ROC



Since the discovery of human immunodeficiency virus (HIV) as the etiologic agent of acquired immune deficiency syndrome (AIDS) more than a decade ago, tremendous progress has been made in various aspects of this virus and its interplay with the host immune system. The advent of potent combination therapy has made it possible to achieve effective and durable control of HIV-1 replication in vivo, yet the persistence of the latent reservoirs pose a new challenge. The recent identifications of several cellular proteins interacting with different viral gene products have not only shed new insights into our understanding of the HIV-1 and the host cell biology, but also provided the bases for developing novel strategies to block HIV-1 replication. It is from this perspective that we review the current understanding of the molecular mechanisms governing the HIV-1 life cycle.


J Microbiol Immunol Infect 2000;33:131-140.