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Volume 41, Number 6, December 2008

Comparison of clinical characteristics of amebic liver abscess in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients


Kuan-Sheng Wu, Hung-Chin Tsai, Susan Shin-Jung Lee, Yung-Ching Liu, Shue-Ren Wann, Yung-Hsing Wang, Ming-Hsin Mai, Jei-Kuang Chen, Cheng-Len Sy, Kung-Ming Chen, Yi-Jan Chen, Yao-Shen Chen
Section of Infectious Diseases, Department of Medicine, and Section of Microbiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Received: July 2, 2007    Revised: July 24, 2007    Accepted: August 31, 2007   

 

Corresponding author:

Dr. Yao-Shen Chen, Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 81346, Taiwan. E-mail: Dr. Yao-Shen Chen This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
 



 

Background and purpose: 

Amebic liver abscess is an emerging parasitic disease in human immunodeficiency virus (HIV)-infected patients. Clinical characteristics of this disease have rarely been compared between patients with and without HIV infection.
 



 

Methods:

This retrospective study included 24 patients who had been diagnosed with amebic liver abscess during a 17-year period. The demographics, clinical manifestations, radiographic findings, and outcomes were compared between HIV-infected and non-HIV-infected patients.

 



 

Results:

Among 24 patients with amebic abscess, 8 were HIV-infected and 16 were non-HIV-infected. The mean (± standard deviation [SD]) age of HIV-infected patients was 41.0 ± 11.3 years (range, 27-62 years), which was younger than that of the non-HIV-infected group (58.5 ± 14.6 years; range, 27-77 years; p=0.01). Compared with non-HIV-infected controls, patients with HIV infection had lower white blood cell counts (median, 17.2 × 109/L vs 10.4 × 109/L; p=0.01), neutrophil/lymphocyte (N/L) ratio (median, 12.1 vs 2.7; p<0.01), total bilirubin (median, 42.7 µmol/L vs 13.7 µmol/L; p=0.02), blood urea nitrogen (median, 7.9 mmol/L vs 4.1 mmol/L; p=0.04), and creatinine (median, 114.9 µmol/L vs 88.4 µmol/L; p<0.01). On multivariate analysis, low N/L ratio remained a significant predictor for HIV infection (odds ratio, 0.49; 95% confidence interval, 0.264-0.912; p=0.024). No significant differences were observed in clinical manifestations, radiographic findings, and indirect hemagglutination titer between the 2 groups.



 

Conclusion:

HIV-infected patients with amebic liver abscess tended to have a lower N/L ratio than non-HIVinfected comparators.



 

Key words:

Entamoeba histolytica; HIV infections; Liver abscess, amebic; Taiwan

 



 

J Microbiol Immunol Infect. 2008;41:456-461.