Print E-mail
Volume 41, Number 6, December 2008

Association of single nucleotide polymorphisms of MD-1 gene with pediatric and adult asthma in the Taiwanese population


Shih-Wei Lee, Jiu-Yao Wang, Yuan-Chun Hsieh, Ying-Jye Wu, Hsien-Wei Ting, Lawrence Shih-Hsin Wu
Chest Medicine Department of Internal Medicine, Taoyuan General Hospital, Taoyuan; Department of Pediatrics and Institute of Molecular Medicine, College of Medicine, National Cheng-Kung University, Tainan; Product and Research Development Division, Vita Genomics Inc., Taipei; and Department of Neurosurgery, Taoyuan General Hospital, Taoyuan, Taiwan

Received: December 31, 2007    Revised: January 25, 2008    Accepted: March 11, 2008   

 

Corresponding author:

Lawrence Shih-Hsin Wu, PhD, Product and Research Development Division, Vita Genomics Inc., 7 Floor, No. 6, Sec. 1, Jungshing Rd, Wugu Shiang, Taipei County, 248 Taiwan. E-mail: Lawrence Shih-Hsin Wu This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
 



 

Background and purpose: 

MD-1 (myeloid differentiation 1; also known as Ly86, lymphocyte antigen 86), interacting with radioprotective 105, plays an important role in the Toll-like receptor 4 signaling pathway. It has been suggested that MD-1 is involved in the development of inflammation and atopic diseases. The purpose of this study was to investigate the genetic association of single nucleotide polymorphisms (SNPs) of MD-1 and asthma in the Taiwanese population.



 

Methods:

Genotyping 34 SNPs in the MD-1 gene region was performed in a case-control study involving 281 children with asthma and 237 controls. A further 309 children and adults were genotyped for the SNP rs7740529 only, for validation of an identified association.
 



 

Results:

In intron 1, we identified an SNP, rs7740529, which is associated with asthma in Taiwanese children (p=0.0358). Inclusion of a further 309 subjects increased the significance of the association (p=0.0093), and also demonstrated that rs7740529 is associated with adult asthma. The TT genotype confers risk of both pediatric and adult asthma.



 

Conclusion:

These results suggest that MD-1 could be a susceptible gene for asthma in the Taiwanese population.
 



 

Key words:

Adult; Antigens, Dermatophagoides; Asthma; Child; Polymorphism, single nucleotide

 



 

J Microbiol Immunol Infect. 2008;41:445-449.