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Volume 42, Number 2, April 2009

Subcutaneously implanted central venous access device infection in pediatric patients with cancer

Miao-Chiu Hung, Chun-Jen Chen, Keh-Gong Wu, Giun-Yi Hung, Yu-Jan Lin, Ren-Bin Tang
Department of Pediatrics, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan

Received: June 18, 2007    Revised: July 12, 2007    Accepted: August 30, 2007   


Corresponding author:

Dr. Keh-Gong Wu, Department of Pediatrics, Taipei Veterans General Hospital, No. 201, Section 2, Shih Pai Road, Taipei 112, Taiwan. E-mail: Keh-Gong Wu This e-mail address is being protected from spam bots, you need JavaScript enabled to view it


Background and purpose: 

Subcutaneously implanted central venous access devices (SICVADs) are a common route of intravascular access for pediatric patients with cancer. This study was performed to evaluate the risk for SICVAD-related infection in a large consecutive series of unselected children with cancer in a single medical center.




The medical charts of 209 pediatric patients with cancer who received a SICVAD from January 1, 2001 to December 31, 2005 were retrospectively reviewed, and the patients were followed-up until June 30, 2006. The demographics, clinicopathologic features, and infectious complications were collected for analysis.




There were 137,924 SICVAD days (median, 660 days; range, 16-1962 days). The rate of SICVADrelated infections was 0.15 episodes/1000 SICVAD days. There were 21 episodes of SICVAD-related infection among 17 patients, 18 were bloodstream infection among 14 patients and the other 3 were local infection among 3 patients. Sixteen SICVADs were removed, 13 were associated with bloodstream infection and 3 with local infection. Young age (<2 years) was associated with a high risk for SICVAD-related infection. Staphylococcal spp. and fungi were the most common pathogens associated with SICVADs.




The rate of SICVAD-related infection in children with cancer was low. Children younger than 2 years had a higher risk for SICVAD-related infection than older children. Fungi play an important role in SICVADrelated infection.



Key words:

Catheters, indwelling; Child; Neoplasms; Wound infection


J Microbiol Immunol Infect. 2009;42:166-171.