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Volume 42, Number 3, June 2009

Serum immunoglobulin E levels in patients with primary hypogammaglobulinemia — experience from a tertiary hospital in Taiwan


Wen-Ju Tsai, Jeng-Yee Lin, Yao-Hsu Yang, Jyh-Hong Lee, Bor-Luen Chiang
Department of Pediatrics, National Taiwan University Hospital, Taipei; and Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan

Received: March 13, 2006    Revised: May 14, 2008    Accepted: July 31, 2008   

 

Corresponding author:

Dr. Bor-Luen Chiang, Department of Pediatrics, National Taiwan University Hospital, Fl. 7, No. 7 Chung-Shan South Road, Taipei 100, Taiwan. E-mail: Dr. Bor-Luen Chiang This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
 



 

Background and purpose: 

Primary hypogammaglobulinemia has been proposed to be associated with an increased incidence of allergic diseases, but the correlation between the clinical presentation and the serum immunoglobulin E (IgE) level has not been studied in this patient group. This study investigated the correlation of IgE levels and allergic condition in patients with primary hypogammaglobulinemia.
 



 

Methods:

Thirty five patients with primary hypogammaglobulinemia were enrolled from September 2004 to March 2005. Serum IgE levels were measured at clinic follow-up. Information regarding the patient’s history of allergic diseases, including atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and asthma, were collected from chart review and clinic interviews.



 

Results:

Significantly lower mean ± standard deviation serum IgE levels were found in allergic patients with primary hypogammaglobulinemia (123.9 ± 148.8 IU/mL) than in the healthy control group (376.2 ± 471.7 IU/mL) [p < 0.005] or in allergic patients without primary hypogammaglobulinemia (544.1 ± 309.1 IU/mL) [p < 0.001].
 



 

Conclusion:

Serum IgE level is not a suitable diagnostic criterion or treatment guide for allergy in patients with primary hypogammaglobulinemia.



 

Key words:

Agammaglobulinemia; Allergy and immunology; Immunoglobulin E

 



 

J Microbiol Immunol Infect. 2009;42:271-285.